GLYOXYLATE SHUNT AND PYRUVATE-TO-ACETOIN SHIFT ARE SPECIFIC STRESS RESPONSES INDUCED BY COLISTIN AND CERAGENIN CSA-13 IN ENTEROBACTER HORMAECHEI ST89

ABSTRACT Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin.However, the molecular basis of their action is not fully understood.Here, we examined the genomic and transcriptome responses by Enterobacter hormaechei after prolonged exposure to either CSA-13 or colistin.Resistanc

Abstract The SMC (Structural Maintenance of Chromosomes) complexes are composed of SMC dimers, kleisin and kleisin-interacting (HAWK or KITE) subunits.Mutual interactions of these subunits constitute Flywheel Axle the basal architecture of the SMC complexes.In addition, binding of ATP molecules to the SMC subunits and their hydrolysis drive dynamic

Topic models and neural networks can discover meaningful low-dimensional latent representations of text corpora; as such, they have become a key technology of document representation.However, such models presume all documents are non-discriminatory, resulting in latent representation dependent upon all other documents and an inability to provide di

Aggressive infantile fibromatosis encountered in infants and in childhood is an aggressive, infiltrating, non-metastasizing disease characterized by a benign neoplastic histology and has a tendency to recur locally when not excised adequately.Because of local aggressiveness and a high rate of recurrence, wide local excision must be performed by car